Autoimmunity

Biography

Biography: Anna Wajda

Abstract

In systemic lupus erythematosus (SLE), the immune responses, immune homeostasis and self-tolerance is actively regulated by several types of cells as well as cytokines. The aim of our study was to explore whether IL-1, IL-10 and TNFα genetic variants may be associated with SLE. We examined 216 patients with SLE and 552 unrelated healthy controls. The polymorphisms were evaluated by RT-PCR. The IL-1β rs16944 T allele as well as rs1143634 T allele were significantly frequent in SLE patients than controls (p=0.003 and p=0.017, respectively). The IL-10 rs180872 A allele was more frequent in SLE patients (p=0.003), furthermore, the IL-10 rs1800896 G allele was more frequent in controls (p=0.03). The TNF-α rs1800629 A allele was more frequent in SLE patients than in controls (p=0.002). No association was found between of the TNF-α rs361525 and rs1800610 and SLE susceptibility. The genotype-phenotype analysis showed association between the IL-1β rs1143634 and mean value of C3 (p=0.006); the IL-10 rs180872 and AST (p=0.07); the IL-10 rs1800896 and mean value of C4 (p=0.04); TNF-α rs361525 and SLICC (p=0.02); the TNF-α rs1800610 and Pt (p=0.003) and INR (p=0.004). Our study demonstrated that IL-1β and IL-10 genetic variants are associated with SLE susceptibility in Polish population.