A Paradowska-Gorycka
National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland
Title: TGF-β and IL-6 gene SNPs and their serum levels in Polish patients with SLE
Biography
Biography: A Paradowska-Gorycka
Abstract
Because systemic lupus erythematosus (SLE) is a disease with a strong genetic component and the cytokine production was found to be under genetic control, we decided to explore whether polymorphisms located in the TGF-β and IL-6 genes may be associated with SLE. 216 SLE patients and 552 controls were examined for TGF-β rs1800469 and rs1800470 as well as IL-6 rs2069827 and rs1800795. An increased frequency of the TGF-β rs1800469 TT genotype and T allele was found in SLE patients (p=0.02). The TGF-β rs1800470 C allele was more frequent in SLE patients than in controls (45% vs. 40%). We found no association between of the IL-6 rs1800795 and rs2069827 and SLE susceptibility. The genotype-phenotype analysis showed association between the TGF-β 869 T/C and mean value of APTT and INR (p=0.01 and p=0.05, respectively); TGF β -509 C/T and mean value of CRP, ESR, hemoglobin, APTT Pt and INR (p=0.05, p=0.03, p<0.001, p=0.03, p=0.03 and p=0.05, respectively) as well as anti-SSA and anti-Sm presence (p=0.04 and p=0.03, respectively); the IL-6 -174 G/C and SLICC (p=0.05), anti-SSA (p=0.05) and anti-SSB (p=0.05). A higher TGF-β and IL-6 serum level was found in SLE patients compared to controls (both p<0.0001). In SLE patients with the TGF-β-509 TT genotype the TGF-β serum levels were higher than in SLE patients with TGF-β-509 CC and TGF-β -509 CT genotypes. Our results suggested that the TGF β -509 C/T variant may be considered as a genetic marker for SLE in the Polish population.