2^nd International Conference on Autoimmunity November 06-07, 2017 Frankfurt, Germany

Autoimmune Treatment
For the Autoimmune diseases in market there is no specific treatment presented because of its self-killing nature. mostly techniques such as hormone replacement in Type 1 Diabetes Mellitus or Hashimoto's thyroiditis treat outcomes of the auto violent response, thus these are comforting treatments. Dietary manipulation limits the severity of celiac disease. Steroidal or NSAID treatment limits inflammatory response of many diseases. Palliative dealing inflammation is unsafe in Autoimmune Treatment.  IVIG is used for GBS and CIDP. These are Specific immunomodulatory therapies, available in market.

Cytokine and Current Research

Cytokines are minor secreted proteins released by cells have an exact effect on the connections and interactions amongst cells. Cytokines are locally present in autoimmune lesions where they are produced by inflammation which causes autoimmune attack. Cytokines play prominent roles in inflammation and many diseases, cytokines are signal holder having function pass the signal from one cell to other cells in proper manner, the cytokines performance is important in Autoimmune Diseases because of hyperactive signalling by cytokines, which is non-specific and over stimulation of cells. Cytokine plays important role in induction, regulation, and treatment of Autoimmune Diseases.

Neurodisorders 
A neurological disorder is any disorder of the body and nervous system. There are many recognized neurological disorders, some are common, but many rare. The structural, biochemical or electrical abnormalities in the brain, spinal cord or other nerves can result in a neuro disorders. Most of the neurological disorder treatment reduces the pain but not cure the disease, so it’s really hot topic in current research.
 

Antibodies: Engineering and Therapeutics

Antibody engineering has become a well-developed discipline, encompassing discovery methods, production strategies, and modification techniques that have brought forth clinically investigated and marketed therapeutics. The realization of the long-standing goal of production of fully human monoclonal antibodies has focused intensive research on the clinical employment of this potent drug category. The latest research is going on the basic biology of antibodies and on the development, function and future of therapeutic antibodies.

Inherited Autoimmunity
Many autoimmune disorders are passed down from parents to children because of genetic factors that predispose to their occurrence in next progeny, and researchers are closer than ever to unlocking the genetic secrets of their transmission of autoimmune diseases. Disease has a specific genetic mutation but in autoimmune disease multiple genes are involved that is inherited is not a specific gene that causes a specific defect in metabolism but several genes increase vulnerability or susceptibility to autoimmune disease.
 

Clinical Autoimmunity: Current & Future Research

Autoimmune disease contributes substantially to mortality, and health care cost each year for the proper treatment. More than 70 million Americans are currently living with an autoimmune disease and taking Immunosuppressive medications that globally dampen immune responses. These agents are highly effective for many patients and thus remain the current “gold standard” of care. However, the long term treatment of autoimmune diseases and drugs are showing negative effect and not giving proper satisfaction to patients. 

HIV Drugs: Trigger of Autoimmunity

Potentially severe hypersensitivity reactions to the anti-HIV drug abacavir occur through an autoimmune mechanism, resulting from the creation of drug-induced immunogens that are attacked by the body's immune system as all HIV Drugs blocks enzymes and protein synthesis which cause alteration in proteins and enzyme synthesis and autoimmune deformities accrue in HIV Patient.Many times Unexplained arthralgias and myalgias occur in about 5% of patients with HIV, sometimes in association with HIV seroconversion. HIV-associated arthralgia rarely progresses to inflammatory joint disease and is treated symptomatically.

Malignancy: The great Autoimmune Diseases

Cancer is a group of diseases involving abnormal cell growth which producing mutations that affect normal cell growth and division but if Tumors and the cells implicated in autoimmune diseases both express the same inhibitors of cell destruction there is 1 in 3 people with autoimmune diseases will get cancer. Most of the cancer develops in people who have particular autoimmune diseases because of one gene plays many function in body.

Immunotherapy Research 

Immunotherapy is an innovative treatment approach that empowers the human immune system to overcome cancer and Many Immune genetic disease. But immunotherapy has their side effects such as toxicity, generalized pain, and Rashes. To overcome on this problems many organization trying to develop new molecular and genomic therapy’s for better treatment.

Lupus

Lupus is an Autoimmune disease, which means that the immune system mistakes the body's own tissues as foreign invaders and attacks them and it causes swelling (inflammation) and a wide variety of symptoms. Lupus is of three type. Discoid lupus erythematosus—causes a skin rash that doesn't go away. Subacute cutaneous lupus erythematosus—causes skin sores on parts of the body exposed to sun. Drug-induced lupus—can be caused by medications Neonatal lupus—a rare type of lupus that affects new-born’s.

Immune System and Autoimmunity

The human immune system is a complex network of special immune cells and at the core of the immune system have the ability to tell the difference between self and non-self but misguided immune response arise horrible autoimmune conditions by attacking and damaging its own tissues.  

Pediatric Autoimmunity

Autoimmune disorders are the most common chronic diseases in the childhood population in current days and when they occur they can be challenging to diagnose and difficult to treat. Pediatric autoimmune neuropsychiatric disorders are more common in children.

Molecular Immunology

Molecular immunology deals with immune responses at cellular and molecular level. Molecular immunology has been evolved for better understanding of the sub-cellular immune responses for prevention and treatment of immune related disorders and immune deficient diseases. Journal of molecular immunology focuses on the invitro and invivo immunological responses of the host.

Immunometabolism and Autoimmunity

Metabolism and pathogen defense are essential requirements for survival. Mounting an immune response requires major changes to metabolic processes by the immune mediators. Immunometabolism the integration of centralmetabolic pathways and nutrient sensing with antibacterial immunity has revealed that altered cellular energy homeostasis is positioned to contribute to the prevention or resolution of infectious diseases. Inflammasomes appear to be the key regulators of metabolic inflammation by acting as metabolic danger sensors. Cytokines may have an important role in mediating the effects of chronic inflammation in target tissues, the metabolic consequences of specific ‘inflammatory’ mediators.

The eye is the prototypic immune-privileged organ in the body. Its antigens were once believed to be expressed exclusively in the eye, which resides behind an efficient blood-organ barrier or hidden from blood, and were believed to be unknown to the immune system and immune cells. Self-tolerance to ocular components was therefore believed to be based not on immune tolerance but on immune ignorance because of their non-self-Identification. In the Autoimmunity the relationship between the immune system and the eye is complex and many effects arise because of in.