3^rd International Conference on Autoimmunity November 26-27, 2018 Dublin, Ireland (Louis Fitzgerald Hotel)

Autoimmunity is the process of Immune Responses of an organism against its own tissues and cells. Any disease that results from such an unusual immune response is termed an autoimmune disease. An Autoimmune disease is a state arising from antibody-mediated immune response abnormalities to a normal body part. There are at least 80 types of autoimmune diseases. Nearly any body part can be involved. Common symptoms include low grade fever and feeling tired. Often symptoms come and go.

Cytokines are minor secreted proteins released by cells have an exact effect on the connections and interactions amongst cells. Cytokines are locally present in autoimmune lesions where they are produced by inflammation which causes autoimmune attack. Cytokines play prominent roles in inflammation and many other diseases, cytokines are wave holder having the function for passing the wave from one cell to other cells in absolute, manner. The cytokines performance is important in Autoimmune Diseases because of hyperactive waving   by cytokines, which is non-specific and over stimulation of cells.

Metabolism is necessary for pathogen defense and survival of life. In the Immune Mechanism &Immune Metabolism is essential for Pathogen degradation, by immune cells, time of immune metabolic process high level of signals pass to Immune cells to get stimulate and Immunometabolism process get start by central metabolic pathways and antibacterial immunity has revealed. But if similar antigen is present on host cell it altered immune response and starts demonstration of autoimmune response against host cell and Autoimmune Diseases. Metabolic inflammation acts as metabolic hazard sensors. Cytokines have an essential role in mediating the properties of chronic inflammation on target tissues

The Autoimmune illnesses are passed from parents to children because of dominancy of allele and gene mutation, epidemiologic and Clinical indication that the data from inherited autoimmune disease are carry forward to next generation because of its self-assemble nature. Multiple number of genes has been connected which cause autoimmune illness in the human beings major histocompatibility complex primarily genes are responsible to cause Autoimmune Diseases. These genes also called the HLA. Sometimes ecological influences resemble with the hereditary susceptibility for generating autoimmune disease. A few such activates have been identified in Autoimmune research, in which including the drugs, specific Mutagenic chemicals, Biological factors, carcinogenic molecules, and family clustering, sometimes the nutritional elements also responsible for Autoimmune Disorder.

 Bioinformatics is the application of technology of computer for management of biological data. Computers are used to store, gather, analyze and integrate genetic and biological information, which can then be applied to gene-based drug development and discovery.  Bioinformatics is an interdisciplinary playing field that develops software tools and methods for understanding biological data. Bioinformatics database mostly used in protein sequences, in Autoimmune Diseases  by using different databases.

Physiological processes where by the useful changes causing from a particular disease called Pathophysiology. A normal immune system involves in the activation of B and T-cells after getting signal from cytokines of microphage and NK cell, and the immune cells undergo differentiation to produce antibodies and  plasma cells to destroy infection causing partials, subsequently in large amounts T-Cell and B-Cell get activated, the normal immune response is assumed to involve B and T cell responses to the same antigen, conformations on the surface of a molecule for B cells and pre-processed peptide fragments of proteins for T cells. Idiotype Cross-Reaction – Idiotypes are antigenic epitopes originate in the antigen-binding portion (Fab) of the immunoglobulin element.

More than 10, 0000 patients have received an as treatment for a severe autoimmune disease. Transplantation (HSCT) has been used as a treatment for severe and therapy-refractory for autoimmune diseases. Allogeneic Transplant replaces the auto-reactive host immune system and failure of transplantation and graft-versus-autoimmunity effect seen in patient.

To treat Autoimmune Diseases Genetic Engineering & Therapeutics is current research growing wildly in biological research aria, for proper treatment against self-Antigen and new drugs creation, Polyreactive Antibodies; Directed Evolution; Antibody Response; Antibodies in a complex environment; knowledge-based design; and Polyspecificity; is current research going on in research institute. The interface between off-target toxicity; Cellular Immunity in Cancer; Antibody Therapy and Antibodies; Antibody Pharmacokinetics, Cardiometabolic ,Medicine, Optimizing Antibody formats for Immunotherapy,  Polyclonal, Bispecifics, these are top research Therapeutics in genetic engineering.

Lupus is an autoimmune disease, which means that the immune system omission the body's own tissues as external invaders and charge them and it causes inflammation and a wide variety of symptoms will be visible. Lupus is of three types. Discoid lupus erythematosus—causes a skin rash that doesn't go away; sub-acute cutaneous lupus erythematosus causes skin sores on parts of the body exposed to sun. Drug-induced lupus can be caused by medications and different kind of drugs components. Neonatal lupus a rare type of lupus that affects new-born’s children and foetus.

Implicit, severe immune sensitive reactions to the anti-HIV drug abacavir materialize through an autoimmune procedure, resulting from the design of drug-induced immunizing agent that are attacked by the body's immune system as all HIV Drugs blocks protein synthesis and enzymes which cause alteration in and enzyme synthesis, autoimmune deformities accrue in HIV Patient and proteins. Many times foreign myalgia’s and arthralgia’s occur in about 5% of patients with HIV, sometimes in association with HIV seroconversion.  Many bone related diseases and HIV-associated arthralgia started progresses towards inflammatory joint disease and disorders because of HIV Treatment.

Molecular immunology assign with cell mediated immune responses at lymphoblast like cells and molecular level. Molecular immunology has been spread for better knowledge of the sub-cellular immune responses for defending against and treatment of immune related disorders and immune deficient diseases. Journal of molecular immunology focuses on the in-vivo and in-vitro immunological responses of the host.

Autoimmune disorders are the most common chronic diseases in the childhood population in current days and when they occur they can be challenging to diagnose and difficult to treat. Pediatric autoimmune neuropsychiatric disorders are more common in children.

The eye is the illustrative immune-privileged organ in the body. Its antigens were once accept to be solely in the eye, which park behind an expert blood-organ barrier or hidden from blood, and were believed to be undistinguished to the immune cells and immune system. Self-tolerance to ocular elements was therefore admit  to be based not on immune resistance  but on immune shallowness  as a result of their non-self-Identification. In the Autoimmunity the relationship between the eye and the immune system is complex and many effects arise because of in.

Autoimmune disease contributes substantially to mortality and health care cost each year for the proper treatment because of lacking proper treatment on these diseases. More than 70 million Americans are currently living with an autoimmune disease However, the long term treatment of autoimmune diseases and drugs are showing negative effect on host cells. Immunosuppressive medications that globally dampen immune responses in the patient and making susceptible for other diseases are not the way of medication also These agents are highly effective for many patients and thus remain the current “gold standard” of care because of lacking new research in these topics.